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If you are undergoing treatment for Lyme disease and suddenly feel significantly worse — increased fatigue, intensified pain, worsening brain fog, fever, or a flare of your existing symptoms — you may be experiencing a Jarisch-Herxheimer reaction , commonly known as “herxing.” This phenomenon, first described in the treatment of syphilis more than a century ago, occurs when large numbers of bacteria are killed rapidly by antimicrobial therapy, releasing endotoxins and inflammatory mediators into the bloodstream

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