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Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients

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Pharmacokinetic studies in humans reveal: Peak plasma concentrations achieved within 5-20 minutes following subcutaneous injection Absolute bioavailability of approximately 6% with subcutaneous administration Volume of distribution ranging between 23.7-25.8 liters in adult subjects Rapid systemic distribution to target pituitary receptors The peptide’s small molecular size and water solubility facilitate efficient absorption from subcutaneous tissue, though first-pass degradation significantly limits bioavailability compared to intravenous administration