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In vivo study found that intraperitoneal injection of 100 mg/kg silibinin in a surgical EMs mouse model, combined with in vitro treatment of VK2/E6E7 and End1/E6E7 cells with 0–50 μM silibinin, demonstrated that silibinin dose-dependently inhibited cell proliferation, suppressed DNA replication, induced ROS production by modulating the MAPK signaling pathway, thereby promoting apoptosis ( Naringenin is a naturally occurring dihydroflavonoid compound

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Pathway enrichment analysis via KEGG, using differentially expressed proteins in each phase, identified significant metabolic pathway enrichment throughout development (Fig