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UHPLC was carried out with a binary gradient consisting of 0.5% formic acid in water (A), and 0.5% formic acid in acetonitrile (B) using Acme Xceed C18, 100 mm × 2.1 mm, 1.9 µm columns (Phase Analytical Technology, State College, PA, USA) at a flow rate of 400 µL/min
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Size:250MG
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