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Worse, bigger muscles did not translate into meaningfully better function: a meta-analysis of Novartis's sarcopenia trials found only a nine-meter improvement in six-minute walk distance, not enough, in Klickstein's own judgment, to prevent falls

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When applied to the skin, it may also cause mild skin or eye irritation ( Additionally, there is concern over mixing MSM with alcohol since other sulfur-containing medications can cause adverse reactions when mixed with alcoholic beverages ( However, no studies have explored this potentially problematic combination yet