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Third, we synthesize preclinical and clinical efforts to therapeutically target glutamine metabolism, highlighting limitations, resistance mechanisms, and future directions

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(S)-2-amino-4-oxo-5-hydroxyvaleric acid (RI-331), a homoserine dehydrogenase inhibitor, acts through an enzyme-assisted suicide mechanism by irreversibly binding to and inactivating Hom6p, an enzyme involved in amino acid biosynthesis, ultimately leading to fungal cell death (Yamaki et al., 1992)