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In Prp-TDP-43 A315T mice, dysregulated expression of estrogen-related enzymes (CYP19A1 and CYP3A4) was observed relative to wild-type controls, which suggested that toxic phosphorylated TDP-43 oligomers may disrupt the balance between CYP19A1 and CYP3A4 expression, resulting in reduced estrogen biosynthesis and accelerated degradation

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4 Mechanisms through which Ganoderma lucidum polysaccharides contribute to the prevention and treatment of diabetes Long-term hyperglycemia in diabetic patients can cause numerous complications, significantly impacting their quality of life and safety (Shaw et al., 2009)