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In brief, acyl-ghrelin synthesis via GOAT in brain is minimal [40, 41] and unlike desacyl-ghrelin, is poorly blood-brain barrier (BBB) permeable during normal physiological states
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Some users describe this as a “leaning effect,” though it’s important to frame this carefully: IGF-1 LR3 isn’t a stand-alone weight loss solution, but rather a potential support tool for body composition when combined with lifestyle changes
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