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AcrIF19 exerts dual-functional PatCas2/3 inhibition via a sequential mechanism To contextualize AcrIF19’s functional distinctiveness within anti-CRISPR mechanisms, we conducted comparative analyses against two established Cas2/3 inhibitors: AcrIF3 and AcrIF23

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3c), RNA sequencing identified 785 differentially expressed genes (DEGs), with the levels of 296 genes upregulated (Supplementary Data 1) and 489 genes downregulated (Supplementary Data 2) in FBXL5 ΔCD11c mice compared to those in control mice after APAP treatment

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