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In the absence of MPC activity, import of pyruvate into the mitochondria is greatly diminished, meaning that less acetyl-CoA can be produced by Pyruvate Dehydrogenase and that TCA cycle flux is diminished (Gray et al., 2015, Rauckhorst et al., 2017)
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Further, trimetazidine’s demonstrated safety and tolerability provide a strong rationale for clinical trials to test its efficacy to treat bipolar depression that could fast-track its repurposing to address such an unmet need as bipolar depression
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