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(46) demonstrated that administration of SIN (10–30 mg/kg, i.p.) led to detectable levels in rat brain and significantly reduced infarct size in a middle cerebral artery occlusion (MCAO) model, via inhibition of acid-sensing ion channel 1a and L-type calcium channels
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The sheet is flanked by helices α1 (residues 15–26) and α3 (residues 71–81) on one side and on the other by α2 (residues 41–51) including the short 3 10 helices α2 and α2′
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