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British anatomist and physician, Thomas Willis in the 17th century stated the first clinical description of RLS and later on in 1945 Swedish neurologist Ekbom, characterized the neuropathological syndrome more specifically
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Receptor downregulation has been defined experimentally as the decrease in the number of radioligand binding sites detected on the cytomembrane, which is generally caused by repeated and/or continuous activation of receptors [18]
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