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Additionally, the CNS can regulate intestinal barrier function and microbiota composition through the vagus nerve, affecting the entry of enterogenous endotoxins into the liver and activating the inflammatory responses [77]

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Some PDI family enzymes also engage in disulfide bond reduction to promote protein folding (13), the ER-associated degradation of misfolded proteins (14–16), or the ER-to-cytosol retrograde translocation of a bacterial cholera toxin and non-enveloped viruses (17–19)