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Based on this correlation between the absence of lid loop and hydrolysis of higher molecular weight substrates, it has been proposed that lid loop containing enzymes would not be able to utilize polymeric substrates due to closed catalytic pocket
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Co-enzyme B12 also interacts with the enzyme methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), required for the conversion of homocysteine to methionine, which is essential for folic acid metabolism and the formation of thymine, which is a component of DNA
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