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Design, synthesis, and pharmacological evaluation of embelin–aryl/alkyl amine hybrids as orally bioavailable blood–brain barrier permeable multitargeted agents with therapeutic potential in Alzheimer’s disease: Discovery of SB-1448
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Mechanistically, ox-LDL induces lipid peroxidation by inhibiting the SREBP-1/SCD1/FADS2-mediated lipid biosynthesis pathway, leading to endothelial damage and ultimately inducing ferroptosis ( 3.3 Ferroptosis and the inflammatory response The discovery of ferroptosis may explain iron accumulation's biological effects
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