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No receptor has been cloned, no gene encoding it has been identified, and no precursor protein has been characterised — a state of affairs summarised in Kovalzon and Strekalova's 2006 review, which called the peptide a still unresolved riddle and remains the standard reference for exactly that reason

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Although there are several methods to increase permeability of peptides, here, we intend to outline some of the applicable enhancement approaches that have been used successfully for other anti-wrinkle peptides