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A Human Microglial Cell Line Expresses γ-Aminobutyric Acid (GABA) Receptors and Responds to GABA and Muscimol by Increasing Production of IL-8
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The sesquiterpene lactone-enriched fraction from Xanthium mongolicum Kitag exhibited the strongest anti-RA activity, which dose-dependently (from 1 to 640 μg/mL) decreased the expression of M1-related genes IL-6, -1β, TNF-α, -12b, and iNOS through the suppression of NF-kB signaling [160]
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