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351 In the process of ferroptosis, cells are affected by oxidative stress and lipid peroxidation, resulting in the rupture of cell membranes and cell death, which is manifested mainly by the reduction in GPX4, the core enzyme of the antioxidant system (glutathione system), and the high expression of the lipid peroxidation marker 4-HNE

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Its chemistry is conventional peptide chemistry and its characteristic failure modes are the conventional ones, deletion and truncation impurities from synthesis and slow hydrolytic and isomerization routes in solution