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For instance, second mitochondrial-derived activator of caspases (SMAC) analogs targeting inhibitor of apoptosis protein (IAP) can antagonize IAPs and promote apoptosis by mimicking endogenous SMAC proteins (82)

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By blocking NNMT, 5-Amino-1MQ redirects nicotinamide towards NAD⁺ production, restores methyl pool availability, suppresses adipogenesis, and shifts adipocyte metabolism towards a less lipogenic phenotype and making it a uniquely targeted research tool for studying the intersection of NAD⁺ biology, fat cell metabolism, and obesity at the enzyme level