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As we age, because the retinal cells, the cells of the eye are so metabolically active, they accumulate a lot of reactive oxygen species, and mitochondrial repair and limiting reactive oxygen species is a major theme of trying to rescue vision
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Conversely, synovial-derived cytokines such as IL-1β and TNF-α further stimulate chondrocytes, aggravating lipid peroxidation and ferroptosis (140, 141)
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