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ACLS : : cardiac arrest epinephrine (IV push) is a primary drug used in treating cardiac arrest improves perfusion pressure to brain & heart (due to vasoconstrictor effects) improves cardiac output (due to increasing heart rate, contractility & AVN conduction) : bradycardia & post-cardiac arrest hypotension epinephrine can be given by IV infusion or via endotracheal tube improves blood pressure, perfusion pressure, heart rate, contractility & AVN conduction NOTE: As outlined in current ACLS protocols, atropine is more commonly preferred as a drug of choice for treating symptomatic bradycardia

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Another multitarget MOR-DOR agonist, SRI-22141, was tested in the clinically relevant models of HIV neuropathy and chemotherapy-induced peripheral neuropathy, in which it was found that while providing equal or enhanced efficacy versus morphine, the tolerance was significantly reduced, with almost non-dependence during the course of repeated administration [59]