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NaBPC157 (10 ⁇ g or 10 ng/kg b.w., i.p.) or saline (5.0 ml/kg b.w., i.p.) was applied either 1 hour before or 1 hour after both carotid arteries were ligated for 3 or 6 hours in rats

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Larazotide's barrier-restoration effect addresses the bidirectional gut-oral microbiome relationship — strengthening the mucosal defense layer that systemic inflammation and periodontal disease progressively erode