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Morphine has a bioavailability of about 30% because 70% is metabolized via 1st pass effect (metabolism by the liver) if taken orally
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In accordance with this, we demonstrated that increased Fabp5 expression in DKO* skin was restored by inhibiting TNFα and IL-17 pathways, but circulating Fabp5 was not changed, and joint phenotypes remained unaffected, suggesting that local Fabp5 levels may reflect skin disease severity [57]
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