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Because bilirubin can pass through the glomerular filtration barrier, an increase in conjugated bilirubin in blood will rapidly spill into the urine, thus a bilirubinuria usually precedes a bilirubinemia due to increases in conjugated bilirubin or when there is cholestasis (the exception is delta bilirubin

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GATA4 mutations are a cause of neonatal and childhood-onset diabetes