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Even if certain ORI DDSs show favorable release profiles in vitro under acidic conditions, it cannot be guaranteed that they will function effectively in all tumors, especially in those with high heterogeneity (Shen et al., 2024).Although targeted ORI DDSs demonstrate high selectivity, in the complex tumor microenvironment, targeting molecules may sometimes fail to bind precisely to the target receptors, particularly in tumors with heterogeneous expression of these molecules (Sun et al., 2024)
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Furthermore, activation transcription factor 3 (Atf3) reduces Acsl4m6 A modification level by up-regulating FTO expression, thus inhibiting ferroptosis (35)
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