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Our recent research showed that NAD + decline promoted epithelial-mesenchymal transition (EMT), migration, and invasion of cancer cells by activating the STAT3 signaling pathway and oxidatively degrading 15-hydroxyprostaglandin dehydrogenase (15-PGDH, an NAD + -dependent enzyme) via accumulated ROS
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Neither of these rationales is without merit, but it’s worth being precise about what the evidence does and doesn’t support
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