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These remedies not only improve metabolism but also play a role in tissue regeneration, mitochondrial efficiency, and immune system adjustments—showcasing the broad implications of focusing efforts toward cellular signaling pathways such as AMPK, PI3K/AKT, and mTOR
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Conversely, SIM1 overexpression reduces food ingestion and body weight in mice fed a high-fat diet, acting downstream of melanocortin receptors [70]
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