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Frontiers | The impact of the exposome on cytochrome P450-mediated drug metabolism

[104] in TNBC cell lines showed that tetrathiomolybdate (TM), an oral copper-chelating agent, destabilizes complex IV by depleting copper, leading to its degradation and, consequently, decreasing OXPHOS

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461,462,463,464 Notably, recent studies further support the pivotal role of NRF2 in intracellular metabolic reprogramming during hepatocyte proliferation, demonstrating its involvement in promoting glycolysis, nucleic acid synthesis, the oxidative pentose phosphate pathway (PPP), and NAD + /NADH synthesis, while downregulating OXPHOS