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People with a higher level of NNMT have been associated with obesity and type-2 diabetes

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It exists because of a specific and testable hypothesis: that the lipolytic activity attributed to growth hormone resides in a discrete C-terminal domain, and that this domain can be excised from the protein and used on its own without carrying along the growth-promoting, IGF-1-inducing and insulin-antagonizing activities that require the intact molecule and its receptor-binding surfaces