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Mechanistically, QSYQ promoted mitochondrial biogenesis (via upregulating PGC-1α, Nrf1, and TFAM) and mitochondrial dynamic homeostasis (by enhancing fusion proteins MFN-2 and OPA1 while inhibiting excessive fission through reduced phosphorylation of Drp1 at Ser616), thereby inhibiting ferroptosis in cardiomyocytes both in vivo and in vitro [195]
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About 98% of L-carnitine stores are found in the muscles, with trace amounts in the liver and blood
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