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Park et al suggested that the anti-proliferative and pro-apoptotic effects of quercetin might be achieved through regulation of MAPK and PI3K/Akt signaling pathway transduction.6 Jamali et al showed that the combined application of quercetin and metformin exerted anti-inflammatory effects by decreasing the inflammatory cytokine TNF-α.230 Increased expression of antioxidant enzymes can attenuate the oxidative stress response.213 Quercetin could promote the expression levels of the Nrf2 gene and enhance the activity of its downstream target gene/antioxidant enzyme (NQO1).230 Kim et al demonstrated that mTOR played a negative regulatory role in the autophagy pathway.231 In a surgically induced endometriosis model, the expression of the mTOR gene was reduced in ectopic endometriotic lesion tissues, and gene expression levels of autophagy markers (Beclin 1 and ATG5) were significantly increased.230 Resveratrol Resveratrol (Figure 9) is a naturally occurring polyphenolic compound which is extensively present in grapes, red wine, and peanuts.232 Resveratrol possesses pro-apoptotic,233 anti-angiogenic,234 anti-inflammatory,235 antioxidant236 and anti-tumor237 biological properties

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