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Microglia are involved in every aspect of neurodevelopment.[210,258] Full activation of primed microglia leads to a release of high levels of chemokines, cytokines, interferons, and inflammatory prostaglandins, as well as an assortment of excitotoxic amino acids, such as glutamate, aspartate, and quinolinic acid

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There are five main mammalian isozymes, which vary in the structure (amino acid sequence and subunit), tissue distribution (liver, kidney,erythrocyte, blood plasma, among others), location (cytoplasm, intestine, extracellular f uid), and substrate specif city (hydrogen peroxide and lipid hydroperoxides) (Dudek et al., 2002)