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We also finalized that, for a drug or biological product eligible for NCTAP that is also approved for new technology add-on payments, we will reduce the NCTAP for an eligible case by the amount of any new technology add-on payments so that we do not create a financial disincentive between technologies eligible for both the new technology add-on payment and NCTAP compared to technologies eligible for NCTAP only (86 FR 45162)

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These two observations have led to the conclusion that a genetic predisposition to thiamine deficiency and its effects may exist, as will be discussed in more detail in the section “Differential Sensitivity to Thiamine Deficiency.” Research over the past 30 years has identified several mechanisms through which alcoholism may contribute to thiamine deficiency