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Similarly, Saracatinib, a selective Src family kinase inhibitor, has shown considerable promise for IPF treatment ( Ex vivo experiments using precision-cut lung slices from IPF patients and mouse models further confirmed saracatinibβs ability to downregulate fibrotic genes, reduce collagen accumulation, and decrease Ξ±-SMA-positive areas
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[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Zhu W., Buffa J.A., Wang Z., Warrier M., Schugar R., Shih D.M., Gupta N., Gregory J.C., Org E., Fu X., et al
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