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Notably, in RA patients with low disease activity, a 12-week course of low-dose sirolimus (0.5 mg every other day) also exhibited a favorable safety profile, elevating Treg levels and enhancing clinical outcomes without evidence of toxicities—such as hemorrhagic cystitis or liver fibrosis—that are associated with certain conventional immunosuppressive agents (142)
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Lab, animal, and small human studies answer different questions
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