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It is also thought that the production of the cytokine IL- 18 that occurs with HHV-6 infection will increase the formation of CD4+ cells in the environment adjacent to cells infected with HHV (Akira).The increased release of IL- 18 could affect the cells in the local cellular environment during HHV-6 replication, and combined with the increase production of the proteins associated with CD4 account for the increased production of CD4+ that occurs during HHV-6 infection
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