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In sulfate-reducing organisms, Cys is the first organic product of S assimilation and is readily available as the precursor for GSH, CoA, and other S- metabolites

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The delayed onset of RTT symptoms is believed to be associated with the postnatal accumulation of methylated CpA dinucleotides (mCpA) and MECP2 binding to these sites, contributing to progressive neurodevelopmental abnormalities (110)