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The factor responsible turned out to be a small copper-binding tripeptide whose endogenous concentration declines with age — from roughly 200 ng/mL at age 20 to 80 ng/mL at age 60. The 50-year research arc that followed makes GHK-Cu one of the most thoroughly characterized small peptides in the literature

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When U87 MG cells were exposed to demethoxycurcumin (DMC) at inhibitory concentrations (0–50 μg/mL), a corresponding increase in ROS production and apoptosis was noted (Kumar et al., 2018)