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Consequently, SIRT1βs role extends to Type 2 diabetic osteoporosis, where vitamin K2 promotes bone mass by activating the adenosine monophosphate-activated protein kinase (AMPK)/SIRT1 signaling pathway to suppress ferroptosis
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Although reduced calcein fluorescence reflects either esterase inhibition or membrane permeabilization, the assay nonetheless captures a biologically meaningful relationship between oxidative burden and cellular dysfunction
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