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Vitamin B12 deficiency also causes an increase in homocysteine levels, which leads to endothelial dysfunction and results in fragmentation of erythrocytes to schistocytes
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Mechanistically, it was proposed that p53 promotes the nuclear translocation of USP7, a DUB to remove ubiquitin from H2Bub, resulting in decreased H2Bub occupancy on the SLC7A11 promoter and subsequent SLC7A11 transcriptional repression (Fig
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