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The experimental dose protocol was well tolerated, with 5.6% of the patients manifesting grade 4 neutropenia

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Paired BM and PB concentrations of ADO and INO at baseline and at DARA treatment failure are shown for each patient, together with derived ADO/(ADO + INO) and INO/(ADO + INO) ratios and best response to DARA therapy (IMWG criteria)