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10.1124/jpet.109.158402 [DOI] [PubMed] [Google Scholar] 18.García-Martín E, Ayuso P, Martínez C, Agúndez JAG (2007) Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals

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Class I comprises severely deficient ( 80% in Brazil and Central America) are expected to have the Class III A- variant[103] which has been termed “mild”, it is important to note that severe hemolysis following treatment with dapsone[104] as well as favism[105] have been observed in individuals with this variant