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Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

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Shared: both escape IGF binding proteins · both act on the IGF-1 receptor · both are injected · neither has a human trial · neither is FDA approved · both carry hypoglycemia and IGF-1 axis concerns IGF-1 LR3 StrategyAdds 13 residues plus a substitution Length83 amino acids Occurs naturallyNo DurationLonger, and the figure is disputed FramingSustained systemic signal OriginBuilt as a cell culture reagent Receptor affinityEquivalent or slightly reduced Specific concernSustained exposure and axis suppression IGF-1 DES StrategyRemoves 3 residues Length67 amino acids Occurs naturallyYes, in colostrum DurationShorter, and the figure is disputed FramingShort local pulse OriginIsolated from tissue, later synthesized Receptor affinityHigher, by a disputed amount Specific concernHigher receptor affinity, unmeasured in people Summary compiled from published research and regulatory records