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A meta-analysis of 12 case-control studies, comprising a total of 3649 cases and 5705 controls found that a high maternal coffee consumption increased a risk of acute lymphoblastic leukemia in childhood (OR = 1.43), whereas low to moderate tea consumption was inversely associated (odds ratio (OR) = 0.85, CI = 0.75–0.97), although the trend was not significant [98]

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Oxidative stress is also a major contributor to ischemic stroke, where MnSOD levels are often reduced in affected patients [204]