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Branched-chain amino acid and cancer: metabolism, immune microenvironment and therapeutic targets | Journal of Translational Medicine | Springer Nature Link
Restriction of dietary AGEs can reduce and/or reverse these effects by enhancing insulin sensitivity and upregulating AGE-R1 and SIRT1 expression while suppressing NF-κB, tumor necrosis factor-alpha (TNF-α), leptin, and serum AGEs in type 2 DM 55
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At this stage, proinflammatory mediators, including interleukins, TNF-α, inducible nitric oxide synthase, and chemokines, are produced
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