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In severe cases, subacute combined degeneration of the spinal cord may occur [13] [14] Glossitis and mouth ulcers : A sore, red tongue and recurrent oral ulceration Mood changes : Depression, irritability, and in rare cases, psychosis It is important to note that symptoms can be subtle initially, and some individuals remain asymptomatic despite biochemical deficiency

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GHK-Cu naturally declines from approximately 200 ng/mL at age 20 to around 80 ng/mL at age 60, correlating with reduced tissue regenerative capacity