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However, it has remained unclear whether GH induces cell expansion directly through GHRs expressed on these cells, or indirectly via stimulation of secondary growth factors produced by granulosa cells, such as IGF, which would then directly act on theca cells (32, 33)

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Mo trained by β-glucan can induce TI, causing increased H3K27ac modification and deposition of H3K4me1 and H3K4me3 gene promoters, leading to transcriptionally active chromatin (102, 197)