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SDHAF1, LYRM7) mediated an interaction with the cochaperone HSC20, and likely guided insertion of Fe-S clusters into the Fe-S subunit of respiratory chain complex II (Figure 4), and, possibly, into complex III [37]

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However, during hypoxic stress or upon NF-κB inhibition, E2F1 access is restored, Bnip3 expression is induced, and mitophagy is activated to promote cell death and mitochondrial quality control