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Vitamin B12 Injections

It is stated by the group that invented the molecule, in the paper announcing a follow-up compound built specifically to fix that limitation: they describe SLU-PP-915 as a chemically distinct ERR pan-agonist that is orally bioavailable, noting that SLU-PP-332 improves aerobic performance in mice but lacks oral bioavailability (a Journal of Pharmacology and Experimental Therapeutics paper characterizing the orally active ERR pan-agonist SLU-PP-915 and stating that the earlier SLU-PP-332 lacks oral bioavailability)

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It works intracellularly by inhibiting NNMT to preserve NAD+ and shift adipocyte metabolism — a completely different mechanism, with different research read-outs