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Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine
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Iron accumulation and lipid peroxidation in β-cells, driven by mitochondrial dysfunction and inflammatory cytokines like IL-1β and IFN-γ produced by T cells and macrophages, lead to β-cell dysfunction and apoptosis (105, 106, 109, 146)
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